APOPTOSIS-INDUCING EFFECT OF AFLATOXIN B1, OCHRATOXIN A AND ZEARALENONE COMBINATION IN RAT HEPATOCYTES

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Submitted: 2025-03-10; Published: 2025-03-10

This work is licensed under Creative Commons Attribution–NonCommercial International License (CC BY-NC 4.0).

Abstract

Aflatoxin B1 (AFB1), ochratoxin A (OTA) and zearalenone (ZEA) are widespread mycotoxins with carcinogenic properties, contaminating feed and food. In this study the apoptosis-inducing effect of AFB1, OTA and ZEA combination at concentrations close to the natural contamination, in rat hepatocytes after 15, 30 and 60 days treatment in vivo is presented.