CELL-FREE MITOCHONDRIAL DNA IN DOXORUBICIN-TREATED KCL22 AND K562 CELL LINES

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Submitted: 2025-03-01; Published: 2025-03-01

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Abstract

Cell-free mitochondrial DNA (cf-mtDNA) is widely used as a biomarker of pathological processes, but its application for assessing the effects of environmental factors is limited. For the first time, cf-mtDNA was identified in the KCL22 cell culture treated with doxorubicin, which is known for its ability to disrupt mitochondrial functions. The results obtained indicate the effectiveness of using cf-mtDNA as a biomarker of genotoxic and cytotoxic effects.