CHEMOSELECTIVITY OF AMINOMETHYLATION OF AMINO- AND ALKOXYETHANOLS IN CHARGE UNITS OF GENERAL THEORY OF ACIDS AND BASES

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Submitted: 2025-03-05; Published: 2025-03-05

This work is licensed under Creative Commons Attribution–NonCommercial International License (CC BY-NC 4.0).

Abstract

The evidence on the violation of chemoselectivity of aminomethylation of dimethyl- and diethylaminoethanol, which occurs under the influence of hydrogen bond was received. The same hydrogen bond occurs in the oxygen analogues of aminoethanols and β-alkoxietanols, but contrary to expectations, it is not accompanied by a change in the chemoselectivity of the reaction. We propose a rationale to explain the differences in the properties of these molecules, using charge units of the ionic character of the bond.