Natural Sciences, Stomotology, 2026
ISSN: 1829-006X
COMPARATIVE CLINICAL AND MICROBIOLOGICAL EFFECTS OF 0.12% CHLORHEXIDINE ON PMMA VERSUS POLYAMIDE DENTURE BASES: A CONTROLLED STUDY ANCHORED TO ISO 20795-1
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Submitted: 2026-04-08
© 2026 by author(s) and The Gufo Inc.
This work is licensed under Creative Commons Attribution–NonCommercial International License
(CC BY-NC 4.0).
Abstract
Objective: To compare the clinical, microbiological, immunological, and ISO-aligned laboratory effects of a 14-day
0.12% chlorhexidine (CHX) regimen on PMMA versus polyamide denture bases.
Methods: Forty edentulous participants were allocated to PMMA (n=20) or polyamide (n=20). Primary outcomes were.
Budtz-Jørgensen denture plaque index and Newton’s classification; secondary outcomes included PI, GI, GCF
cytokines (IL-6, TNF-α), Candida CFU/cm², and ISO 20795-1 laboratory metrics (Ra, ΔE, flexural properties,
sorption/solubility).
Results: Both materials demonstrated significant clinical and microbiological improvements after CHX, whereas
PMMA exhibited greater surface and color changes; polyamide showed superior esthetic stability.
Conclusions: CHX is an effective short-term adjunct regardless of base material; material-dependent surface/esthetics
effects should guide maintenance protocols.