Natural Sciences, Stomotology, 2026
ISSN: 1829-006X
EVALUATION OF ANTIBACTERIAL AND ANTI-INFLAMMATORY EFFECT OF GREEN SYNTHESIZED SILVER OXIDE NANOPARTICLES FROM MANILKARA LITTORALIS FOR BIOMEDICAL APPLICATIONS
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Submitted: 2026-04-08
© 2026 by author(s) and The Gufo Inc.
This work is licensed under Creative Commons Attribution–NonCommercial International License
(CC BY-NC 4.0).
Abstract
Objective:This study investigates the antibacterial and anti-inflammatory effects of silver oxide nanoparticles (AgO
NPs) synthesized using a green approach with Manilkara littoralis extract, highlighting their potential in biomedical
applications.
Methods:AgO NPs were synthesized by reducing silver nitrate with Manilkara littoralis leaf extract, confirmed by
color change. Characterization involved FTIR, UV-Vis spectroscopy, XRD, and SEM. Antibacterial efficacy was
assessed against S. aureus and E. coli using the disk diffusion method, while anti-inflammatory properties were
tested in a zebrafish model.
Results:AgO NPs exhibited strong antibacterial activity, especially against Gram-positive bacteria. Antiinflammatory effects were observed in zebrafish embryos with minimal adverse impacts, indicating favorable
biocompatibility.
Conclusions:AgO NPs synthesized from Manilkara littoralis show promise as a dual-function therapeutic agent for
potential biomedical applications, particularly in infection control and inflammation management. Further research
is needed to explore their full clinical potential.