SYNTHESIS, CHARACTERISATION AND EVALUATION OF NEODYMIUM DOPED BIOGLASS–AN INVITRO STUDY

Background: In the pursuit of advancing antimicrobial strategies, neodymium-doped bioactive glasses have emerged
as potential material due to their unique physicochemical properties. This in vitro study aimed to evaluate the
antimicrobial role of neodymium-doped bioactive glass, exploring its inhibitory effects against a spectrum of
pathogenic microorganisms.
Materials and Methods:Neodymium-doped bioactive glass with varying concentrations of neodymium was
synthesized using a sol-gel method. Characterization techniques, including Fourier-transform infrared spectroscopy
(ATRIR), and scanning electron microscopy (SEM), were employed to confirm the glass’s structural integrity and
neodymium incorporation.
Results: Characterization confirmed the successful synthesis of neodymium-doped bioactive glass, with XRD patterns
revealing the amorphous nature of the glass and FTIR spectra indicating the presence of characteristic bioactive glass
bands. SEM images illustrated the homogeneity of neodymium distribution within the glass matrix.
Conclusion: The neodymium-doped bioactive glass synthesized in this study demonstrated pronounced antimicrobial
activity against a broad spectrum of microorganisms. The concentration-dependent inhibitory effects suggest a potential role for neodymium-doped bioactive glass in combating bacterial and fungal infections. The enhanced antimicrobial efficacy, particularly against Gram-positive bacteria, positions neodymium-doped bioactive glass as a promising material for applications in various biomedical fields.