BIO-CHEMICAL PROPERTIES OF CURCUMIN AND CURCUMIN ANALOGUE-2 AND CURCUMIN ANALOGUE-2 IN THE TREATMENT OF PERIODONTAL DISEASE.A NARRATIVE REVIEW

Periodontitis is an inflammatory disease which affects both soft and hard tissues. Many treatment options have been employed to treat periodontitis out of which scaling and root planing are the standard procedures to initially reduce inflammation and improve tissue conditions. Although, scaling and root planing can reduce the inflammation, other agents or adjuncts should be used which can decrease the inflammation systemically or locally in an effective manner without side effects of using antibiotics. One of the traditional herbs used in Chinese and Indian ayurveda is Curcumin. Curcumin is known for its anti-inflammatory antioxidant and anti-microbial effect. As Curcumin is less stable with less bioavailabilty, there is need for formulation of Curcumin analogues which are long lasting, highly stable and also have high bioavailability. Curcumin analogue -2 is known to have high anti-inflammatory, antimicrobial and antioxidant effect which can combat with periodonto-pathogenic bacteria and the inflammation due to periodontal supporting tissues. Therefore, this review focuses on bio-chemical properties of Curcumin and its formulated Curcumin analogue -2 and mechanism of Curcumin analogue -2 in the treatment of periodontitis.