Natural Sciences, Stomotology, 2026
ISSN: 1829-006X
EVALUATION OF EXPRESSION OF SALIVARY ICTP BIOMARKER IN PERIODONTITIS PATIENTS – AN OBSERVATIONAL STUDY
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Submitted: 2026-04-08
© 2026 by author(s) and The Gufo Inc.
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(CC BY-NC 4.0).
Abstract
Objectives: Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is released during the breakdown of Type I collagen which is the primary event which happens in periodontitis. In this study, we primary intention is to find if ICTP biomarker can be used in the diagnosis of periodontitis. Materials and methods: 30 patients were included. On clinical examination, they were divided into 3 groups 10 healthy, 10 chronic periodontitis patients and 10 chronic periodontitis with diabetes patients. Unstimulated saliva was collected from these patients. Presence of salivary ICTP was assessed using ELISA and qPCR. Results: The highest ICTP levels were seen in Group 3 which is diabetes with periodontitis, followed by group 2 and group 1. A statistically significant difference was observed when ICTP levels were compared when Group 1 was compared with Group 3 and similarly with Group 2. Conclusion: Significant difference in the salivary ICTP levels between the gingivitis and periodontitis groups proved that ICTP can be used as a tool for the diagnosis of periodontitis.