Keeping specific diets is one of the main points in managing many diseases. It is also known that the intake of certain food might provide predictable shifts in gut bacterial communities in diseases. On the other hand, probiotics are suggested to restore the unfavourable changes in gut microbiota. Moreover, food enriched with specific probiotics might be the basis of certain diets, but the selection of probiotics and its targeted delivery through food requires serious scientific-technological approaches to stimulate/keep the growth of probiotic through synbiotic nutrition.
Periodic disease /PD, FMF, familial Mediterranean fever/, the autosomal recessive and systemic autoinflammatory disorder, is characterized by recurrent bouts of fever, serositis, synovitis, and/or cutaneous inflammation. A low-salt/low-fat diet may be used in the management of PD patients. The exact role of intestinal bacteria is not yet fully understood, but the potential for host-microbiota dialogue is widely discussed in the pathogenesis of PD.
This study aimed to clarify whether the investigations on DNA methylation of gut commensal E. coli from FMF patients had actuality for evaluating host-microbiota dialogue.
The following keywords- E. coli, gut, FMF and DNA methylation were used to collect data from PubMed (1990-2021).
The analysis of the literature data substantiated the usefulness of the investigations on DNA methylation of gut commensal E. coli in FMF disease for the evaluation of hostmicrobiota dialogue.