Effects of Pearl Yangxin Anshen Decoction on HAMD and PTSD-SS Scores, Cytokines and Related Metabolites in Patients with Post-Traumatic Stress Disorder
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Effects of Pearl Yangxin Anshen Decoction on HAMD and PTSD-SS Scores, Cytokines and Related Metabolites in Patients with Post-Traumatic Stress Disorder Min Guo
Objective: This paper aims to observe the Pearl Yangxin Anshen Decoction
to influence the score of HAMD and PTSD-SS, the changes of the cytokines
and the related metabolic product in patients with PTSD. Methods: From
June 2015 to May 2016, in the traditional Chinese medicine clinics of Hainan Province People’s Hospital, there were 50 patients with PTSD, the age
were from 30 to 60, they were randomly divided into treatment group (25
cases) and control group (25 cases), then compared the scores of HAMD and
PTSD-SS between the two groups, searched the changes of cytokines and the
related metabolic product. Results: In the treatment group: before and after
treatment the scores of PTSD-SS were 65.64 ± 7.02, 28.32 ± 4.18, and the
scores of HAMD were 29.28 ± 1.97, 11.72 ± 2.13; In the control group: before
and after treatment the scores of PTSD-SS were 63.24 ± 6.16, 31.40 ± 4.29, the
scores of HAMD were 30.24 ± 2.05, 13.08 ± 2.30. After 3 months patients in
treatment group the scores of PTSD-SS and HAMD were lower than the control group (t = 2.570, P = 0.013, t = −2.1640, P = 0.035). In the control group:
before and after 3 months treatment the IL-2 levels respectively were 79.84 ±
26.46 pg/ml, 56.18 ± 22.67 pg/ml, the IL-6 levels respectively were 110.83 ±
47.65 pg/ml, 59.67 ± 44.68 pg/ml, the IL-8 levels respectively were 73.11 ±
78.51 pg/ml, 55.83 ± 81.94 pg/ml, the NE levels respectively were 420.04 ±
674.75 pg/ml, 185.31 ± 417.91 pg/ml, the MDA levels respectively were 112.35
± 62.87 ng/ml, 60.42.33 ± 53.64 ng/ml, the NO levels were 126.6 ± 47.4
µmol/L, 78.6 ± 45.7 µmol/L, the VIP levels were 396.6 ± 144.4 pg/ml, 122.4 ±
111.5 pg/ml. In the treatment group: before and after 3 months treatment the
IL-2 levels respectively were 86.00 ± 32.29 pg/ml, 53.84 ± 27.01 pg/ml, the IL-6
levels respectively were 108.21 ± 44.60 pg/ml, 42.46 ± 42.16 pg/ml, the IL-8 levels respectively were 81.48 ± 94.19 pg/ml, 54.07 ± 84.15 pg/ml, the NE levels respectively were 392.93 ± 592.84 pg/ml, 243.85 ± 588.45 pg/ml, the
MDA levels respectively were 117.58 ± 63.37 ng/ml, 45.91 ± 38.94 ng/ml, the
NO levels respectively were 135.9 ± 46.4 µmol/L, 72.6 ± 46.6 µmol/L, the VIP
levels respectively were 414.0 ± 140.1 pg/ml, 185.8 ± 105.3 pg/ml. In the two
groups as the extension of treatment time, the content of IL-2, IL-8, IL-6, NE,
MDA, NO, and VIP were gradually reduced, and the level of reduction of the
treatment group patients was higher than the control group, the change of
ACTH and SOD levels just the opposite. Conclusion: The Pearl Yangxin
Anshen Decoction could improve the symptoms of psychological anxiety,
depression and other psychological problems in patients with PTSD, and influence the change of cytokines and related metabolites product.
DOI: 10.4236/jbbs.2024.143007 Journal of Behavioral and Brain Science, 14 93-102
