Acute exacerbation of chronic obstructive pulmonary disease with polymorphic phagocytic cells

Chronic obstructive pulmonary disease is a progressive non-communicable disease due to the chronic inflammation response. An acute exacerbation is a weighting of the symptoms experienced by the patient before. Acute exacerbations of Chronic obstructive pulmonary disease are thought to be associated with acute inflammation involving pro-inflammatory cells. Bangil Hospital data in 2019, Chronic obstructive pulmonary disease patients reached 2928 and 388 exacerbation events. Study aims to analyze the correlation between acute exacerbation of chronic obstructive pulmonary disease with polymorphic phagocyte cells in the Emergency Department of Bangil Hospital, Indonesia.
This was a cross-sectional retrospective study. We collected the patient who came to the emergency room with acute exacerbation event and recorded the number of times the patient experiences an acute exacerbation event and the results of a complete blood lab polymorphic phagocyte cell, including basophils, neutrophils and eosinophils from the medical record. Data analysis in this study used the Spearman method to determine the correlation between Chronic obstructive pulmonary disease exacerbation and polymorphic phagocyte cells.
Chronic obstructive pulmonary disease exacerbations 1-5 times were obtained in 54 patients.
The patients were 41 males (75.9%) and 13 females (24.1%). The chronic obstructive pulmonary disease patients were 46-65 years (n=31, 52.4%), >65 years (n=21, 38.9%), and 26-45 years (n=2, 3.7%). Patients who had moderate symptoms were 34 patients (61.1%), severe symptoms 7 patients (12.9%), and mild symptoms 13 patients (24.1%). Statistical test results showed an association of acute exacerbation of chronic obstructive pulmonary disease with basophils (p=0.018), neutrophils (p=0.001), and eosinophils (p=0.0012).
This study concludes there is a correlation between the incidence of acute exacerbation and chronic obstructive pulmonary disease with polymorphic phagocyte cells.