Effects of anti-allergic therapy on blood pressure, symptoms of rhinitis and level of C-reactive protein in patients with comorbid allergic rhinitis and hypertension

The task of this research was to study the effects of three treatment regimens of anti-allergic therapy on clinical and functional parameters, symptoms of rhinitis, control of blood pressure and systemic inflammation in patients with seasonal allergic rhinitis and essential hypertension.
Totally 73 patients were examined (men – 34 people (46.5%) and women – 39 people (53.5%). All patients were divided into three clinical groups depending on the treatment of seasonal allergic rhinitis.
All patients were examined for nasal and non-nasal symptoms of seasonal allergic rhinitis, which was conducted on the total nazal symptom score and total non nazal symptom score 2 times a day (morning and evening), a standardized rhinitis quality of life questionnaire was used to assess the quality of life of patients, blood pressure control was conducted using 24-hour holter monitoring and the level of hs-c-reactive protein was studied. These parameters were studied twice: 3-5 months before the period of pollination (stage 1) and in the period of pollination (stage 2).
In the period of pollination cause-significant allergens in the 2nd and 3rd clinical groups were found the highest total nasal symptom score, total non nasal symptom score, rhinitis quality of life questionnaire, systolic blood pressure, heart rate and C-reactive protein.
The most effective effect on the control of symptoms of seasonal allergic rhinitis, stability of antihypertensive therapy and the level of systemic inflammation was registered in patients who received allergen specific immunotherapy and started therapy with antihistamines one month before pollination of causal allergens.