ACRYLAMIDE-INDUCED NEUROTOXICITY: NARRATIVE REVIEW

Acrylamide (ACR), a neurotoxic compound found in heat-processed foods, poses significant health risks, including neurotoxicity in both adult and offspring mammals. This review comprehensively evaluates the protective roles of hydroxyapatite (HA) and vitamin B12 (methylcobalamin) against ACR-induced neurotoxicity in male albino rats. By synthesizing findings from in vivo and in vitro studies, this article compares the mechanisms, efficacy, and potential synergistic effects of HA and vitamin B12 in mitigating oxidative stress, neuronal damage, and behavioural impairments caused by ACR exposure. The review highlights the biomaterial properties of HA and the
neuromodulatory functions of vitamin B12, emphasizing their roles in neuroprotection. Gaps in current research, such as the need for transgenerational studies and optimal dosing regimens, are identified to guide future investigations. This article aims to provide a robust foundation for researchers and clinicians exploring therapeutic interventions for ACR-induced neurotoxicity.