Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 110–116
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ASSESSING S100A7 AS A DIAGNOSTIC BIOMARKER IN ORAL CANCER PATIENTS

Sangeetha R*, Bhavna Jha Kukreja, Bharti Gupta, Rakesh Chanda, Anish Gupta, Harleen Sohi, Megha Patel, Sampada Thobbi

Department of Oral and Maxillofacial Pathology, Dayananda Sagar College of Dental Sciences, Bengaluru, Karnataka, India. · Periodontology, Preventive Dental Sciences Department, College of Dentistry, Gulf Medical University, Ajman, UAE. · Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia. · Sree Rama Dental Clinic, Opp. Brother Bawarchi Restaurant, Vivekananda Nagar, HITECH City road, Borabanda, India. · Head, Department of Oral Pathology & Microbiology, People's Dental Academy, People's University, Bhopal, Madhya Pradesh,India · General Dentist in Massachusetts, 416 Tyler Street, Pittsfield, Massachusetts 01201, USA. · Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, India Karnavati University, Gandhinagar, Gujarat, India · Department of Prosthodontics, Dr. D. Y. Patil Dental college and Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune 411018, India

Received: 2026-04-08 · Published: 2025-06-15

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
ASSESSING S100A7 AS A DIAGNOSTIC BIOMARKER IN ORAL CANCER PATIENTS
Authors
Sangeetha R, Bhavna Jha Kukreja, Bharti Gupta, Rakesh Chanda, Anish Gupta, Harleen Sohi, Megha Patel, Sampada Thobbi
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-06-15
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.5-110

Abstract

Background: Oral squamous cell carcinoma (OSCC) is a worldwide issue, and its outlook is poor if detected late. At present, most diagnosis depends on examining tissues, which can be unreliable because different experts may see things differently. Scientists suggest that S100A7, a calcium - binding protein, may be used to identify different malignancies. The meaning of S100A7 expression in distinguishing healthy oral glands, OPMDs, and OSCC was investigated in this study. Material and Methods: Retrospective analyses were made on tissue samples taken from 245 individuals: 89 with OSCC, 78 with OPMD, and 78 people who had normal oral mucosa. Immunohistochemical staining for S100A7 was carried out according to standardized steps. We looked not only at how much the cells stained, but also how many cells were stained for each marker. Data was analyzed with chi - square tests, ROC curves, and multivariate logistic regression. Results: The S100A7 gene was actively expressed in 84.3% of OSCC samples, 61.5% of OPMDs, and 12.8% of normal skin tissues (p<0.001). In 76.4% of OSCC cases, there was strong S100A7 staining, but only 23.1% of OPMD cases showed this pattern. The ROC curve covered 84.2% for the purpose of telling OSCC apart from OPMDs. Nuclear and cytoplasmic S100A7 levels were strongly linked to tumor grade and lymph node metastasis (p<0.05). Conclusion: This biomarker has valuable use for finding oral cancer and grouping patients by their risk levels. Because CEA is expressed at higher levels in cancerous tissues and is linked to worse tumor signs, it is useful in both reviewing and planning treatments for patients with oral cancer.
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