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Abstract
Background: The objective of this study was to evaluate the correlation between ABO blood group types and oral potentially malignant disorders and oral squamous cell carcinoma. According to the earlier study findings (based on available literature), an individual’s susceptibility to certain cancers, such as oral squamous cell carcinoma is influenced by ABO blood type. As one third of oral squamous cell carcinomas develop from potentially malignant disorders it is imperative to identify the association between ABO blood group and these lesions. Materials and Methods: The study was conducted in the Department of Oral Medicine and Radiology in collaboration with Department of Oral Pathology at Malla Reddy Institute of Dental Sciences, Hyderabad on 158 clinically diagnosed potentially malignant disorders and oral squamous cell carcinoma patients. Out of which 122 were males and 36 were females. Patients' ABO blood types were ascertained using the rapid slide agglutination test. Results: The Chi square test was used to determine the statistical relationship between ABO blood types and the risk of oral cavity malignancies. In this study Incidence of Squamous cell carcinoma found to be more in A+ve blood group, Oral Submucous fibrosis more in B+ve blood group, Oral leukoplakia more in B+ve and Oral lichen planus more in O+ve blood group. A statistically significant association was observed. Conclusion:According to this study, the A+ve blood group had a higher incidence of squamous cell carcinoma, the B+ve blood group had a higher incidence of oral submucous fibrosis, the B+ve blood group had a higher incidence of oral leukoplakia, and the O+ve blood group had a higher incidence of oral lichen planus.
