Comparative efficiency of parodontoprotective actions of antidisbiotic preparations “argakol” and “cm-2” in rats after orthodontic surgery on a background of type 2 diabetes mellitus

Comparison of the periodontal protective effect, two antidisbiotic agents were tested on rats after orthodontic surgery on the background of type 2 diabetes mellitus:“Argakol” (contained antimicrobial agents, alginate, collagen hydrolyzate) and “CM-2” (contained extracts of medicinal plants, glycerophosphate Ca, vitamins, trace elements, gelatin). Type 2 diabetes mellitus was induced in rats by protamine. Orthodontic surgery included fixing of the spring. The condition of the gums was assessed by the level of urease, lysozyme, elastase and hyaluronic acid. The state of the periodontal bony tissue - by the activity of alkaline, and acid phosphatases, and the content of calcium and protein. The mineralizing index was calculated by the ratio of phosphatase activity, and the degree of mineralization by the ratio of the content of Ca and protein. The degree of dysbiosis was determined by the ratio of the relative activities of urease and lysozyme.
It was noted an increase in the gum level of urease, elastase and a decrease in the level of lysozyme and hyaluronic acid, more expressed in the combination of type 2 diabetes mellitus and orthodontic surgery. In the bony tissue with type 2 diabetes mellitus, alkaline phosphatase activity decreased, calcium content and acid phosphatase activity increased, more significant in the combination of type 2 diabetes mellitus and orthodontic surgery. Anti-disbiotic applications had the periodontal protective effect (reduced inflammation, dysbiosis, increased mineralization index and the degree of mineralization. “CM-2” turned out to be more effective.
Antidisbiotic agents had a periodontal protective effect during orthodontic operations on the background of type 2 diabetes mellitus.