Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 233–243
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COMPARATIVE EVALUATION OF SALIVARY ALPHA ENOLASE LEVELS IN PATIENTS WITH SUBMUCOUS FIBROSIS AND HEALTHY CONTROLS

Divyani Patil*, Madhura Mahajan, Kamala KA, Ashwini Rani SR Rani SR

Department of Oral Medicine, Radiology and Diagnosis, School of Dental Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, India

Received: 2026-04-08 · Published: 2025-04-03

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
COMPARATIVE EVALUATION OF SALIVARY ALPHA ENOLASE LEVELS IN PATIENTS WITH SUBMUCOUS FIBROSIS AND HEALTHY CONTROLS
Authors
Divyani Patil, Madhura Mahajan, Kamala KA, Ashwini Rani SR Rani SR
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-04-03
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.3-233

Abstract

Oral submucous fibrosis (OSMF) is presently recognized as a potentially malignant disorder (PMD), with the likelihood of developing to oral squamous cell carcinoma ranging between 7 to 30%. Alpha-enolase, a lysosomal enzyme essential to glucose metabolism, is associated in disrupted energy production during carcinogenesis, guiding uncontrolled cell proliferation in numerous cancers. Identifying the connection between OSMF and salivary alphaenolase could offer a helpful means for early diagnosis of malignancy, establishing the path for its application as a biomarker in both diagnosis and treatment. This study seeks to investigate and assess the salivary alpha-enolase levels in OSMF patients to healthy controls, proposing to find possible variations that might contribute to an early diagnostic breakthrough. Material and methods: Saliva samples were taken from 20 participants in each group (OSMF sufferers and healthy controls). Salivary alpha-enolase levels were identified using the sensitive and precise enzyme-linked immunosorbent assay (ELISA). Statistical analysis were carried out using the Independent Sample t-test to establish significance. Results: The results indicated that salivary alpha-enolase levels in OSMF patients were significantly higher in comparison to those in healthy people. Conclusion: Salivary alpha-enolase could become a reliable biomarker for early OSF identification, thereby offering an opportunity for timely intervention, more efficient treatment planning, and improved outcomes for patients.
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