Background: Professional oral hygiene is pivotal in preventing periodontal disease by eliminating supragingival and
subgingival biofilm and calculus. While traditional methods are effective, they may induce discomfort and tissue
trauma. Guided Biofilm Therapy (GBT) is a minimally invasive protocol designed to optimize biofilm removal while
improving patient comfort and operator ergonomics.
Aim: This study compares the Standard Protocol and GBT in terms of clinical efficacy, patient-reported comfort,
treatment duration, and operator experience.
Materials and Methods: The Present in vitro study utilized six subjects’ blood and was centrifugated. T-PRF clots
were prepared, and TI/ NE gel extracts were injected and compared with T-PRF alone to check the release of Vit C,
Az, and IGF 1 at 6hours, 72 hours (3rd), 7th, and 14th day. For statistical analysis, a paired t-test and ANOVA were
performed. P value <0.05 was considered statistically significant.
Results: Over 98% of patients treated with GBT reported reduced or absent pain compared to traditional methods. GBT reduced treatment time by approximately 15% and was associated with improved plaque control, reduced bleeding, and lower probing depths. Operators reported reduced fatigue and improved ergonomics with GBT instrumentation.
Conclusions: GBT offers a clinically effective and patient-friendly alternative to conventional prophylaxis, combining
enhanced comfort with efficient biofilm management. These findings support the integration of GBT into routine oral
hygiene practice to optimize clinical outcomes and patient compliance.
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