EFFECT OF PHYTOCOMPOSITION ON MUCOSAL REGENERATION IN EXPERIMENTAL PROSTHETIC STOMATITIS

The rapid and uneven atrophy of soft tissues and bone structures associated with the use of removable dentures, combined with local inflammatory processes, can damage the neurovascular bundles in the maxillofacial region. This leads to the formation of painful and bleeding wound surfaces on the oral mucosa, which compromise local mucosal defenses and act as portals for infection. For this purpose, solutions derived from plant materials have long been used for disinfection. An experimental study was performed on 60 sexually mature male Wistar rats, aged 8-9 months, with a mean body weight of 350 ± 54 g. Atrophic stomatitis was induced using our proprietary model. A phytosolution—comprising aloe hydrolat and juniper essential oil—was applied topically to the affected oral mucosa. The animals were divided into groups based on the duration of phosphoric acid exposure on the oral mucosa (30 seconds and 90 seconds). The resulting mucosal alterations were characterized by edema, vasodilation, and lymphocytic infiltration of the lamina propria. Topical application of aloe hydrolat was found to reduce edema and inflammation, whereas juniper essential oil promoted accelerated re-epithelialization of the mucosal lesions.