EFFICACY OF COMBINATION NEUROPROTECTIVE DRUGS FOR INFERIOR ALVEOLAR NERVE EXPERIMENTAL TRAUMATIC NEUROPARTHY TREATMENT
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EFFICACY OF COMBINATION NEUROPROTECTIVE DRUGS FOR INFERIOR ALVEOLAR NERVE EXPERIMENTAL TRAUMATIC NEUROPARTHY TREATMENT Dmytro Shabliy
Introductin. Due to the changed nature of out-patient dental care the inferior alveolar nerve traumatic neuropathy has become a common complication in recent years. This is because of frequent use of the inferior alveolar nerve block with vasoconstrictors, higher use of various techniques for the alveolar ridge osteotomy and dental implants placement.
Materials and methods. The experiment was performed in 44 Wistar rats. Inferior alveolar nerve traumatic neuritis was modelled in all the animals. The animals were sacrificed in compliance with the requirements regulating the use of experimental animals at day 1, 3, 10, 30 and 90 by overdosing anesthesia.
The slides were stained with hematoxylin-eosin and using the van Gieson method. Axis cylinders of nerve fibers and myelin sheaths were defined using E.I. Rasskazova’s and Weigart-Pal methods. The succinate dehydrogenase and lactate dehydrogenase activity was assessed using the frozen section method of Nachlas M. and A.Pierse. Specialized microscopes MBI and PEM-100 were used for photographic documentation of the slides.
Results. At post-surgery days 1, 3 and 10 inflammatory and reactive changes and increased circulatory disorders were found in all the slides. The most marked changes with signs of inflammation and edema in perineural tissues were observed in sub-group 2 during day 30.
Events of edema became common and developed into dystrophy by day 30 in the second set of the experiment. Milgamma® helped to relieve the disorders. In sub-group 1-“c” the said signs were less pronounced and reversible due to the use of Cocarnit, in sub-group 2-“c” the said signs were not relevantly different.
By post-surgery day 90 in the first set of the experiment reparative processes in the injured tissues were most pronounced in the former suppurative inflammation area (sub-group 2). In group 1-“m” most animals manifested myelin fibers splitting.
By post-surgery day 90 in the second set of the experiment the animals treated with Cocarnit developed compensatory and regenerative disorders with signs of hardening along with dystrophy. Morphological changes suggestive of less pronounced tissue hypoxia as compared to the first set of the experiment were observed in subgroups 1-“m” and 2-“m” animals by day 90. Milgamma ® helped relieve dystrophic and destructive changes.
Conclusion. The proposed combination therapy of traumatic neuritis facilitated the progress of reparative processes. It is found that Cocarnit is effective for regeneration of all types of fiber while Milgamma has positive effect on regeneration of only injured thin myelin and naked fibers.
DOI: https://ysmu.am/v2/wp-content/uploads/2023/05/e07e4b45.pdf The New Armenian Medical Journal Vol.13 (2019), Nо 3 49-56
