EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF CYNARA SCOLYMUS EXTRACT AND ITS WOUND HEALING POTENCY AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII, IN VITRO AND IN VIVO STUDY

Objectives: Plants extracts known as phytomedicine have immense potential for the management and treatment of wounds. Aim of this study was evaluate the antimicrobial effect and wound healing potency of Cynara scolymus against multidrug-resistant A. Baumannii infection.
Materials and Methods: Cynara scolymus hydroalcoholic extract in comparison with gentamicin antibiotics on clinical strains as well as pathogenic bacteria such as Multidrug-Resistant Acinetobacter Baumannii, under in vitro conditions using micro broth dilution and disc diffusion methods. Moreover, minimum inhibitory concentration and Minimum bactericidal concentration of its hydroalcoholic extract was also evaluated.
Results: The results showed that although Cynara scolymus extract was effective on Multidrug-Resistant Acinetobacter Baumannii. The extract was also tested in the form of topical administration on excision wound model in rats. In the extract-treated wounds, the wound healing percent was significantly increased in comparison with controls.
Conclusions: Based on this research, herbal extract of Cynara scolymus can be a great candidate for the treatment of Multidrug-Resistant Acinetobacter Baumannii infections and merits further studies.