EXPLORING THE ROLE OF LONG NON-CODING RNAs AS BIOMARKERS IN CARDIOVASCULAR DISEASE: A BIBLIOMETRIC ANALYSIS

Background: Cardiovascular diseases (CVDs) are a leading cause of mortality globally, necessitating novel
biomarkers for diagnosis and treatment. Long non-coding RNAs (lncRNAs) have emerged as significant regulatory
molecules in cardiovascular biology, yet comprehensive bibliometric analyses in this area are lacking.
Objective: This study aims to conduct a bibliometric analysis of lncRNAs as biomarkers in CVD to identify
publication trends, key contributors, and thematic developments from 2008 to 2023.
Methods: A systematic search was performed across PubMed, Scopus, and Web of Science using the keywords
“((Long non-coding RNA) OR (lncRNA)) AND (Cardiovascular disease) OR (Cardiovascular disorders) AND
(Biomarkers).” A total of 33,805 records were retrieved, with duplicates removed, resulting in 29,545 unique
records. After screening, 341 relevant articles were selected for bibliometric analysis using VOSviewer.
Results: A total of 341 publications were analyzed, involving 54 countries/regions, 548 institutions, and 1744
authors across 177 journals. The United States (84 publications) and China (61 publications) were the leading
contributors. Zhengzhou University had the highest publication output, while Guo Wei was the most prolific
author. Keyword analysis revealed a focus on lncRNAs’ roles in the occurrence, development, diagnosis, treatment,
and prognosis of CVD.
Conclusion: This bibliometric analysis provides insights into the research landscape of lncRNAs as biomarkers in
CVD, highlighting significant trends, influential authors, and collaborative networks. The findings underscore the
importance of lncRNAs in cardiovascular research and suggest potential areas for future investigation