Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 170–176
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FABRICATION AND CHARACTERIZATION OF VITAMIN C CONJUGATED CISSUS QUADRANGULARIS MEMBRANE FOR GUIDED TISSUE REGENERATION - AN IN VITRO STUDY

Sneha Harshini*, Jayalakshmi Somasundaram, Balaji Subramanian, Gurumoorthy Kaarthikeyan

Department of Periodontics,Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · 2Reader,White lab - Materials Research centre, Saveetha Dental College and hospitals,Saveetha Institute of Medical and Technical Sciences (SIMATS),Saveetha University,Chennai -77, Tamilnadu, India. · Reader, Department of Periodontics,Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Head of Department, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India

Received: 2026-04-08 · Published: 2025-06-25

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Originally published in Bulletin of Stomatology and Maxillofacial Surgery, 2025 — https://doi.org/10.58240/1829006X-2025.21.5-170.

Original title
FABRICATION AND CHARACTERIZATION OF VITAMIN C CONJUGATED CISSUS QUADRANGULARIS MEMBRANE FOR GUIDED TISSUE REGENERATION - AN IN VITRO STUDY
Authors
Sneha Harshini, Jayalakshmi Somasundaram, Balaji Subramanian, Gurumoorthy Kaarthikeyan
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-06-25
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.5-170

Abstract

Background: Cissus quadrangularis has gained attention for its rich content of bioactive compounds, including flavonoids, carotenoids, and polyphenols, notably Vitamin C.These compounds are recognized for their antioxidant, anti-inflammatory, and tissue reparative properties, may provide the membrane more bioactivity, which would encourage cell division and proliferation.This main aim of this study is the production of vitamin C membrane impregnated with Cissus quadrangularis for soft tissue regeneration. Materials and Methods: To prepare the vitamin C membrane with the impregnation of Cissus quadrangularis (CQ) , 1 gram of CQ was dissolved in 10 mL of distilled water and heated at 80°C for 24 hours. Following membrane formation, FTIR (Fourier Transform InfraRed Spectroscopy), contact angle, tensile strength testing and antimicrobial activity was compared between the CAR control group membrane and the test group membrane which contains CAR with the impregnation of vitamin C. Results: The tensile strength of the test group was better than the control group. The test group showed the tensile strength of 23.86 N whereas the control group showed 27.99 N. CAR membrane had a contact angle of 81.88 degrees. This implies lower wettability. Whereas the cissus quadrangularis and vitamin C incorporated membrane had a contact angle of 49.92 degrees. The test group showed better wettability, tensile strength and anti microbial activity as compared to the control group. Conclusions: The present study showed that CAR membranes with the impregnation of Cissus quadrangularis showed increase in hydrophilicity. The mechanical property was increased and the antimicrobial activity showed an enhanced zone of inhibition. The membrane can serve multipurpose dental applications and can be incorporated in various periodontal procedures for guided tissue regeneration.
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