This work is licensed under Creative Commons Attribution–NonCommercial International License
(CC BY-NC 4.0).
In modern and machinery life, it has been established that inflammatory reactions and oxidative stress play an important role in the onset and progression of numerous common metabolic diseases.
Environmental factors such as dietary factors are underlying these modern diseases.
In this systematic review and meta analysis, clinical randomized trials of effect of chromium supplementation on inflammatory and stress oxidative indices will be searched by the prespecified search strategy in PubMed, Scopus, International Scientific Indexing, Proquest, Cochrane, clinical trial.gov and Google Scholar. Quality (risk of bias) of relevant articles will be assessed by Cochrane software. Design ,disease type, sample size, supplement dose, study duration, before and after intervention mean ± standard deviation of outcomes (inflammatory cytokines and stress oxidative mediators) will be extracted from included studies. The overall effect size of intervention will be expressed as weighted mean differences in the Random Effect Model. Subgroup analyses will be based on the dosage and duration of chromium supplementation, health condition of the participants, study location and sample size. The comprehensive meta-analysis software will be used for data analysis. P values <0.05 will be considered as statistically significant.