NUTRIGENOMICS -AN ENIGMA TO PERIODONTAL DISEASES

Background: Nutrigenomics is used to learn about how genes and diet together may affect an individual’s health and risk of developing diseases and also to prevent and treat disease. It also helps in the interaction between nutrients with the genome at the molecular level to get insight into the role of nutrients that may affects or influences health. Periodontitis results from imbalance between host and microbial response which results in improper functioning of periodontal tissues. Although there are several novel techniques to readdress and restore the function of periodontal structures, Nutrition can act as an anti-inflammatory component and can decrease the incidence of systemic conditions such as cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Crohn’s disease which are known to be associated with periodontal diseases. Nutrigenomics is an area of nutrition and periodontics which is involved with the influence of diet and its components on the genome, proteome, and metabolites. Materials and methods: This review was reported per the PRISMA guidelines. PubMed, Scopus, Web of Science, Google scholar was searched using pre-specified search strategy. Narrative and systematic reviews are included for the data synthesis Results: Extensive literature search was carried out using pre-defined search strategy was carried out. A total of 48 titles were screened rigorously by two independent evaluators and after duplicate exclusion, removal of irrelevant titles, 15 articles were included for full text. This article reviews nutritional impact and impact of nutrigenomics on periodontitis.