Abstract

Background: Under both normal and pathological conditions, the RANKL-OPG (Receptor Activator of NF-κB Ligand-Osteoprotegerin) system is an essential regulator of osteoclastogenesis and bone resorption. In order to evaluate OPG's potential as a diagnostic biomarker for periodontal disease, this study aimed to assess osteoprotegerin levels in the gingival crevicular fluid of patients with chronic periodontitis, including those with diabetes mellitus, smokers, and systemically healthy individuals. Materials and Methods: The study included 60 subjects of age group above 18 years and distributed into 3 groups. GCF was collected and samples were analyzed for OPG concentration using ELISA assay. Results: No significant difference in PI and GI between 3 groups. PPD shows significant difference between smokers and diabetes with periodontitis. Concentration of OPG is lower in diabetes milletus and smokers when compared to healthy periodontitis. Conclusions: OPG is the marker for bone resorption and can show negative correlation with the clinical parameters like PPD, CAL, thus its increase in levels would denote lesser bone resorption.

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