Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 277–281
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OSTEOPROTEGERIN IN PERIODONTAL DISEASE A CROSS-SECTIONAL STUDY

Mudambi Prakash Pavani*, Laxman Boyapati, Pratisha Rahulkar, Markonda Anusha, Padmavati Bhoomireddy, Kranti Kosuru

Reader, Department of Periodontology, Meghna institute of Dental sciences, Nizamabad · , Department of Periodontology, Meghna institute of Dental sciences, Nizamabad · Department of Periodontology, Meghna institute of Dental sciences, Nizamabad

Received: 2026-04-08 · Published: 2025-06-30

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
OSTEOPROTEGERIN IN PERIODONTAL DISEASE A CROSS-SECTIONAL STUDY
Authors
Mudambi Prakash Pavani, Laxman Boyapati, Pratisha Rahulkar, Markonda Anusha, Padmavati Bhoomireddy, Kranti Kosuru
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-06-30
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.5-277

Abstract

Background: Under both normal and pathological conditions, the RANKL-OPG (Receptor Activator of NF-κB Ligand-Osteoprotegerin) system is an essential regulator of osteoclastogenesis and bone resorption. In order to evaluate OPG's potential as a diagnostic biomarker for periodontal disease, this study aimed to assess osteoprotegerin levels in the gingival crevicular fluid of patients with chronic periodontitis, including those with diabetes mellitus, smokers, and systemically healthy individuals. Materials and Methods: The study included 60 subjects of age group above 18 years and distributed into 3 groups. GCF was collected and samples were analyzed for OPG concentration using ELISA assay. Results: No significant difference in PI and GI between 3 groups. PPD shows significant difference between smokers and diabetes with periodontitis. Concentration of OPG is lower in diabetes milletus and smokers when compared to healthy periodontitis. Conclusions: OPG is the marker for bone resorption and can show negative correlation with the clinical parameters like PPD, CAL, thus its increase in levels would denote lesser bone resorption.
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