Pathogenetic mechanisms of severe course of corona viral infection in obese patients

Obesity is one of the most serious diseases resulting in disability and high mortality. The problem of obesity existed before COVID-19 (Corona Virus Disease 2019) pandemic. It is proved that patients with obesity are most at risk to get infected and having a severe course of the infectious disease. In the contemporary world combination of obesity and a new corona viral infection is of a special significance. The increased risk of severe consequences of COVID-19 in people with obesity is also determined by the high reliability of developing “a cytokine storm”. Obesity is a source of chronic inflammation as it is accompanied by the production of pro-inflammatory cytokines and an increase of acute phase proteins. At present many peculiarities of the course of corona viral infection are revealed against the background of obesity. Among them are: presence
of severe respiratory failure, high risk for developing respiratory distress syndrome, thrombosis and thrombo-embolic complications, as well as worsening of chronic cardio-vascular diseases. In the current situation questions of conservative treatment, considering the mechanisms of virus penetration into the cell, peculiarities of its pathophysiology and interaction with the human organism, obtain a special actuality.