Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 154–169
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PHYTOCHEMICAL-INFUSED SCAFFOLDS: THE ROLE OF CISSUS QUADRANGULARIS IN ADVANCING BONE TISSUE ENGINEERING: A SYSTEMATIC REVIEW

Balaji Ganesh Subramanian*, Sneha Harshin, Taniya Martin, Gurumoorthy Kaarthikeyan, Meenakshi Kuma

Reader, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Department of Periodontics,Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · 3Research Scholar Saveetha Dental College and hospitals,Department of Anatomy Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Head of Department, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · Assistant Professor, Department of Anatomy Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India

Received: 2026-04-08 · Published: 2025-06-25

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
PHYTOCHEMICAL-INFUSED SCAFFOLDS: THE ROLE OF CISSUS QUADRANGULARIS IN ADVANCING BONE TISSUE ENGINEERING: A SYSTEMATIC REVIEW
Authors
Balaji Ganesh Subramanian, Sneha Harshin, Taniya Martin, Gurumoorthy Kaarthikeyan, Meenakshi Kuma
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-06-25
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006x-2025.21.5-154

Abstract

Introduction: Cissus Quandrangularis has been used in traditional medicine for centuries for its repair of bone fractures, joint health, osteoporosis prevention, antibacterial, analgesic, anti-inflammatory, antioxidant properties. When this herb is mixed in modern day research of bone engineering, the greater demand of bone grafts and graft failure can be met. Therefore this study aimed to assess the effect of Cissus quandrangularis infused scaffolds in bone regeneration in various cell cultures. Materials and Methods: Last 10 year published english articles from pubmed, scopus, web of science etc were searched for inclusion in the review. Original invitro research investigating the effect of Cissus Quandrangularis based scaffolds on Cell cultures were included. Data extraction was done by two authors and risk of bias was determined by QUIN guidelines. Results: After the data was extracted, 12 studies out of the 51 that were assessed were included. Ten of the twelve research that were included used human cell cultures, while the other two used murine cell lines. Alkaline phosphatase activity was the primary test employed in the included trials for bone regeneration. Nine of the twelve studies that were included employed this.Alkaline phosphatase activity (ALP activity) is a biochemical assay that can be used to detect the enzyme alkaline phosphatase, which is involved in dephosphorylation reactions. Conclusion:The bone regenerative potential of Cissus quadrangularis-infused scaffolds using both animal and human cell cultures is proved by all the 12 studies with positive results. This avoids the biological complications of allografts and autografts.
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