Polyamines and Gamma-synuclein as possible biomarkers of the malignancy degree of papillomas . Possibilities of the combined use of “DFMO” and “Armenicum” as effective means for symptomatic therapy of papillomas

At present, a subject of a broad discussion are aspects related to the search of biomarkers for assessing the severity of many malignant and benign neoplasms, and more specifically as informative criteria for their early diagnosis and prognosis. The tactics for palliative treatment of malignant diseases, as is known, is based on clinical and laboratory test systems in which specific biomarkers are pathognomic for each disease.
At the same time, such biomarkers are not specified for papillomas of various localization and severity degree. This circumstance, first of all, concerns the papillomas of internal organs (larynx, breast, prostate, cervix), especially when they are classified as papillomas of high severity, with a tendency of their malignancy.
In this publication, the subject of discussion are literary sources, in which, the possible role of aliphatic polyamines – putrescine, spermidine and spermine, is considered as diagnostic and prognostic criteria for the appearance of papillomas in internal organs. According to the authors of this review article, shifts in the content of polyamines in plasma and erythrocytes and in the papillomatous cells can be considered as criteria for the degree of transformation risk of benign cells into malignant. Moreover, the subject of special study should be the researches aimed at clarifying the role of γ-synucleins in the process of papillomatous cell malignancy and the search for new means of symptomatic therapy of high-risk papillomas.