Possible polyamine-dependent mechanisms indicat ing the systemic characteristics of CoVid-19. New approaches in the correction of symptomat ic therapy of CoVID-19
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Possible polyamine-dependent mechanisms indicat ing the systemic characteristics of CoVid-19. New approaches in the correction of symptomat ic therapy of CoVID-19 Arto Zilfyan
The present report provides information on aspects of the pathogenesis of the infectious process induced by SARS-CoV-2. The authors put forward a hypothesis according to which COVID-19 should be considered as an infectious disease of a systemic character. This conclusion was based on some facts, which are hardly possible to deny.
Firstly, from our viewpoint, a number of authors have expressed a well-grounded opinion, according to which, “multiple organ dysfunction syndrome” occurs in COVID-19. Therefore, such a conclusion testifies in favor of systemic damage to organs and tissues.
Secondly, a number of studies, also cited in this publication, provide information on the involvement of the gastrointestinal tract organs in the infectious process caused by SARS-19, which allowed the authors to put forward the concept of the existence of the lung-gastrointestinal tract axis.
This conclusion is based on studies which establish that SARS-CoV-2 by receptor mechanism binds to angiotensin-converting enzyme-2, which is localized throughout the digestive system. Thirdly, in our opinion, it is possible that a similar enzyme receptor uptake mechanism of ACE-2 by SARS-CoV-2, which is competitive with angiotensin-2, is involved in many internal organs, which makes it possible to start a general pathological process, which also indicates the systemic nature of COVID -19.
Fourth, it is possible that SARS-CoV-2 has a widespread cytotoxic effect on blood cells, which is also realized through the receptor mechanism. Apparently, the process of thrombus formation with partly involvement of “deformed erythrocytes” in it has systemic character, especially since SARS-CoV-2, in our opinion, for its functional activity begins to “utilize” polyamines contained in erythrocytes.
This report presents our own concept of possible mechanisms of thrombus formation that occur exclusively in all organs involved in COVID-19 infection.
Since aliphatic polyamines localized in target cells and in the very nucleocapsids of SARS-CoV-2 are given an important role in ensuring the functional activity of SARS-CoV, the authors of this publication recommend the use of drugs that prevent the synthesis of polyamines in the general treatment regimen for COVID-19. As such means, the authors of this publication support the well-founded recommendations of a number of advanced researchers who recommend the use of α-difluoromethylornithine in COVID-19, since this compound has a unique ability to suppress the synthesis of polyamines at the earliest stages of their synthesis, i.e. enzymatic transformation of ornithine into putrescine.
DOI: https://ysmu.am/v2/wp-content/uploads/2023/05/8a3509fc-1.pdf The New Armenian Medical Journal Vol.15 (2021), Nо 3 4-15
