Possible role ofaliphatic polyam ines in the inhibition process of daughter viruses replication in COVID-19 infection. Expediency of adding -difluoromethylornithine to the registry of drugs for COVID-19 infection

Present article is based on the analysis of very informative literary sources, which provide information on the role of aliphatic polyamines in the replication processes of a wide range of viruses pathogenic for humans. Available scientific achievements in this direction most likely indicate that some viruses pathogenic for humans contain polyamines, which are directly involved in the replication processes of daughter viruses.
As the “depletion of the polyamine reserve” of viruses, the latter begin to use polyamines localized in the target cells of the infected organism to maintain replication processes. In our opinion, erythrocytes and polyamine-rich resident microorganisms migrating to the lungs as a result of bacterial translocation can act as other intracorporeal sources for persistent viruses.
The possible role of bacteriophages in the “utilization” processes of bacterial polyamines is being discussed. We discuss a thesis, according to which one of the mechanisms involved in viral-bacterial coinfection, providing access to viruses of bacterial polyamines, at the depletion stage of polyamines in the target cell of the macroorganism, is bacteriophagy, manifested, at least by the presence of “transformed” viruses in the form of monovalent and typical phages (T-phages).
We make the assumption that it is possible that COVID-19, like another representative of the coronavirus family – the Middle East Respiratory Syndrome (MERS-CoV), contains polyamines that are so necessary to ensure their replication in a macroorganism.
In connection with the above, in case of coronavirus infection caused in patients with COVID-19, it is advisable, if not necessary, in our opinion, to conduct studies that are presented in a chronic aspect: To determine the content of polyamines in patients infected with COVID-19, in plasma, blood erythrocytes and pulmonary exudate, depending on the severity of the pathological process, After analyzing laboratory studies (conducting high-performance liquid chromatography (HPLC) for the determination of polyamines in the above biological objects) carry out clinical studies by including α-difluoromethylornithine, a known blocker of aliphatic polyamine synthesis, in the general treatment regimen for COVID-19.
All patients infected with COVID-19, regardless of the pathological process severity, should be recommended a special diet, using exclusively products characterized by an extremely low (or absence) content of aliphatic polyamines.