RANK LIGAND-OSTEOPROTEGERIN SYSTEM AS A DIAGNOSTIC TOOL IN OSTEOPOROSIS

Background: Osteoporosis is a systemic disease of the skeletal system, characterized by low mineral density and
the deterioration of the micro-architecture of the bone tissue, with a consequent increase in bone fragility which
has a significance for dentists and TMJ specialists as well.
Aim: The purpose of this study was to analyze the importance of the Receptor Activator of Nuclear (RANK)
ligand-osteoprotegerin system in bone metabolism and evaluate what may be predicting factors of early diagnosis
while taking into consideration the impact of gender.
Methods: In this study diagnostic strategies are proposed in situations predisposing to osteoporosis. The RANK
ligand-osteoprotegerin system could be an excellent tool for prevention.
Conclusion: Prevention remains the best strategy in avoiding the development of this disorder which can be
disabling but also it could be leading to lethal consequences if neglected. The use of specific screenings such as
those using RANK-ligand osteoprotegerin can be useful to reduce the onset of the disease. Furthermore, due to its
significantly different impact in males vs. females.