Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 255–261
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RANK LIGAND-OSTEOPROTEGERIN SYSTEM AS A DIAGNOSTIC TOOL IN OSTEOPOROSIS

Saccomanno Sabina*, Francesco Bove, Francesca Greco, Giorgio Bove, Elisabetta Guercio, Gabriele Bove, Franklin Garcia-Godoy, Daniela Prosperi

Department of Life Science, Health, and Health Professions LINK Rome Italy 2.President of the Foundation AILA, Italy · President of the Foundation AILA, Italy · Department of Radiology, Nuovo San Giovanni Battista Hospital, Foligno, Italy · Member of the osteoporosis commission OMCeO in Rome, Italy. · .Head of center of the osteoporosis Omnimed, Italy · Head of center of the osteoporosis Omnimed, Italy · Department of bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA · Nuclear Medicine Unit Santa’ Andrea University Hospital Rome Italy, Italy

Received: 2026-04-08 · Published: 2025-05-18

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
RANK LIGAND-OSTEOPROTEGERIN SYSTEM AS A DIAGNOSTIC TOOL IN OSTEOPOROSIS
Authors
Saccomanno Sabina, Francesco Bove, Francesca Greco, Giorgio Bove, Elisabetta Guercio, Gabriele Bove, Franklin Garcia-Godoy, Daniela Prosperi
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-05-18
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.4-255

Abstract

Background: Osteoporosis is a systemic disease of the skeletal system, characterized by low mineral density and the deterioration of the micro-architecture of the bone tissue, with a consequent increase in bone fragility which has a significance for dentists and TMJ specialists as well. Aim: The purpose of this study was to analyze the importance of the Receptor Activator of Nuclear (RANK) ligand-osteoprotegerin system in bone metabolism and evaluate what may be predicting factors of early diagnosis while taking into consideration the impact of gender. Methods: In this study diagnostic strategies are proposed in situations predisposing to osteoporosis. The RANK ligand-osteoprotegerin system could be an excellent tool for prevention. Conclusion: Prevention remains the best strategy in avoiding the development of this disorder which can be disabling but also it could be leading to lethal consequences if neglected. The use of specific screenings such as those using RANK-ligand osteoprotegerin can be useful to reduce the onset of the disease. Furthermore, due to its significantly different impact in males vs. females.
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