Natural Sciences, Stomotology, 2026
ISSN: 1829-006X
THE EFFECT OF Lactobacillus plantarum IS-10506 IN EXCESSIVE RESPIRATORY TRACT INFLAMMATION FOLLOWING SMOKE INHALATION
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Submitted: 2026-04-08
© 2026 by author(s) and The Gufo Inc.
This work is licensed under Creative Commons Attribution–NonCommercial International License
(CC BY-NC 4.0).
Abstract
Background. Smoke inhalation induces injury to the respiratory tract and lung parenchyma through exposure to
smoke and toxic chemicals. Lactobacillus plantarum IS-10506 has been reported to exert anti-inflammatory effects
on the respiratory system. This study aimed to evaluate the efficacy of Lactobacillus plantarum IS-10506 in
attenuating respiratory tract inflammation following smoke exposure.
Methods. Sixteen BALB/c mice were exposed to cotton smoke and randomized into two groups: a control group
(no probiotic treatment) and a treatment group receiving Lactobacillus plantarum IS-10506. Neutrophil counts in
bronchoalveolar lavage fluid were measured, and lung histopathology was evaluated to assess inflammation.
Results. The treatment group demonstrated lower median inflammation scores and neutrophil counts compared to
the control group. However, these differences were not statistically significant (p = 0.232 for histological
inflammation; p = 0.376 for neutrophil count).
Conclusion. Administration of Lactobacillus plantarum IS-10506 was associated with a reduction in
histopathological lung inflammation and neutrophilic infiltration in mice following smoke inhalation, though the
findings did not reach statistical significance.