Natural Sciences, Stomotology, 2026
ISSN: 1829-006X
PREVALENCE OF GORLIN-GOLTZ SYNDROME AMONG PATIENTS WITH ODONTOGENIC KERATOCYSTS- A RETROSPECTIVE STUDY.
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Submitted: 2026-04-08
© 2026 by author(s) and The Gufo Inc.
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Abstract
Background: Odontogenic keratocyst (OKC) is a distinct developmental odontogenic cyst of the jaws known for its
characteristic behavior. It has a significant association with Gorlin-Goltz syndrome, which is an autosomal dominant genetic disorder. This study aims to assess the association between OKC and Gorlin-Goltz syndrome and to estimate the prevalence of the syndrome in patients with OKC.
Methods: A retrospective study was conducted among patients who reported to the Department of Oral Pathology at Tamil Nadu Government Dental College and Hospital, Chennai over a 15-year period (2018-2022). Patients with a
histopathological diagnosis of OKC were included. Clinical, radiographic findings along with histopathological diagnosis were recorded. Based on the available data, the patients were diagnosed as having Gorlin-Goltz syndrome or not based on the criteria available for identifying the syndrome.
Results: The study population consisted of 120 patients, with a male-to-female ratio of 1.26:1. The mean age at diagnosis of OKC was 40 years. Among the patients with odontogenic keratocysts, 6.6% exhibited clinical features consistent with Goltz-Gorlin syndrome.
Conclusion: The findings indicate that the diagnostic criteria for Gorlin-Goltz syndrome may be expressed differently across various demographic groups.