CISPLATIN I N V I V O INFLUENCE ON LIPID CONTENT OF CHROMATIN ON RAT BRAIN CELLS

The in vivo influence of antitumor drug cisplatin on content of phospholipids and neutral lipids in chromatin fraction on rat brain cells was investigated. It was shown, that the drug action leads to decrease in total phospholipids and neutral lipids content about 24 and 20% correspondingly. In spite of these significant changes of total lipids, the alterations in relative quantities and percentage of individual phospholipids as well as neutral lipids in chromatin were negligible. These results indicate that cisplatin excites universal changes in lipid metabolism in chromatin appreciably reducing the absolute quantities of all individual phospholipid and neutral lipid fractions available in chromatin preparations. The significance of these quantitative changes in development of cisplatin antitumor effects was discussed.