It is shown that the amyloid beta peptides Aβ(1-16) and Aβ(1-40) and a cytokine from neurosecretory granules of bovine neurohypophysis, Proline Rich Peptide PRP-4, are truncated at the presence of multifunctional dipeptidyl peptidase IV (CD26/DPPIV), widely expressed in different mammalian tissues. It means that these neuropeptides represent substrates of the enzyme. Besides, it appeared that at the presence of CD26/DPPIV the process of Aβ(1-40) aggregation in vitro was hindered.
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Biology
, 2025, Issue 1, pp. 1–10
ISSN Online: 0000-0000
DOI:
10.xxxx/example-doi