Rutgers Robert Wood Johnson Medical School, Cardiovascular Institute of NJ, New Brunswick, NJ, USA · Hôpital Saint Antoine (Hôpitaux Universitaires de l'Est Parisien), Paris, France
Numerous studies have shown that ankylosing spondylitis is associated with an increased risk of cardiovascular disease including heart failure, acute myocardial infarction, stroke, transient ischemic attack, and cardiovascular mortality. This may be a direct result of inflammation or an indirect one from the use of anti-inflammatory drugs needed to treat ankylosing spondylitis, or from the coexistence of traditional risk factors. This is a retrospective case-control study of the occurrence of cardiovascular events in ankylosing spondylitis patients and matched controls. Data was obtained from
the Myocardial Infarction Data Acquisition System, a statewide database containing hospitalizations for cardiovascular diseases in New Jersey. Two types of analyses were performed: unadjusted and adjusted for comorbidities. The odds ratio of developing heart failure in the ankylosing spondylitis group vs. matched controls was 1.59 (95% CI 1.44 - 1.76, p < 0.001) in the unadjusted model and 1.31 (95% CI 1.18 - 1.47, p < 0.001) after adjustment for hypertension, diabetes mellitus, acute kidney failure/chronic kidney disease, chronic liver disease, chronic obstructive pulmonary disease, and
hyperlipidemia. Similarly, risks of myocardial infarction and cardiovascular mortality in ankylosing spondylitis patients were significantly higher in both, unadjusted and adjusted models while odds ratio for transient ischemic attack became non-significant after the adjustment. Ankylosing spondylitis is associated with increased rates of the cardiovascular disease that are probably due of pathophysiologic changes attendant to the disease, as well as the presence of the comorbidities
Hi! I can explain how to publish or share, find articles in your field, format citations and answer questions about fees and licensing. How can I help?
Answers are based on The Gufo’s published policies. Editorial decisions are made by the editorial team.
