Bulletin of Stomatology and Maxillofacial Surgery
2025; 372–377
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ACRYLAMIDE-INDUCED NEUROTOXICITY: NARRATIVE REVIEW

Zamzam Nasrallah Abdel-Moaty*, Rana Ali, Ahmed Galal, Maha Ahmed

Department of Human Anatomy & Embryology, Faculty of Medicine, South Valley University, Qena, Egypt. · Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena83523, Egypt · Department of Human Anatomy & Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt · Department of Pharmacognosy, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt.

Received: 2025-09-29 · Published: 2025-08-23

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
ACRYLAMIDE-INDUCED NEUROTOXICITY: NARRATIVE REVIEW
Authors
Zamzam Nasrallah Abdel-Moaty, Rana Ali, Ahmed Galal, Maha Ahmed
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-23
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.7-372

Abstract

Acrylamide (ACR), a neurotoxic compound found in heat-processed foods, poses significant health risks, including neurotoxicity in both adult and offspring mammals. This review comprehensively evaluates the protective roles of hydroxyapatite (HA) and vitamin B12 (methylcobalamin) against ACR-induced neurotoxicity in male albino rats. By synthesizing findings from in vivo and in vitro studies, this article compares the mechanisms, efficacy, and potential synergistic effects of HA and vitamin B12 in mitigating oxidative stress, neuronal damage, and behavioural impairments caused by ACR exposure. The review highlights the biomaterial properties of HA and the neuromodulatory functions of vitamin B12, emphasizing their roles in neuroprotection. Gaps in current research, such as the need for transgenerational studies and optimal dosing regimens, are identified to guide future investigations. This article aims to provide a robust foundation for researchers and clinicians exploring therapeutic interventions for ACR-induced neurotoxicity.
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