BULLETIN OF STOMATOLOGY AND MAXILLO-FACIAL SURGERY OF Vol․ 1
2023; 54–64
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AN INTEGRATED APPROACH TO TREATMENT OF EDENTULOUS PATIENTS WITH PERIORAL WRINKLES OF THE SKIN

Gagik Hakobyan*, Khachik Khachikyan, Armen Haruthyunyan, Nvard Vanyan, Veronika Romanihina

Professor, Head of Department of Oral and maxillofacial surgery, Yerevan State Medical University after M. Heratsi, Armenia · Professor, Head of Department of Dermatology and Cosmetology Yerevan State Medical University after M. Heratsi, Armenia · Maxillofacial and Plastic Surgon, Astghik Medical Center, Department of Oral and Maxillofacial Surgery, Yerevan State Medical University after M. Heratsi, Armenia · Lectuer department of Prosthodontics Yerevan State Medical University after M. Heratsi, Armenia · Cosmetologist Astghik Medical Center, Yerevan, Armenia

Received: 2025-05-26 · Published: 2023-01-15

© 2023 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
AN INTEGRATED APPROACH TO TREATMENT OF EDENTULOUS PATIENTS WITH PERIORAL WRINKLES OF THE SKIN
Authors
Gagik Hakobyan, Khachik Khachikyan, Armen Haruthyunyan, Nvard Vanyan, Veronika Romanihina
Source journal
BULLETIN OF STOMATOLOGY AND MAXILLO-FACIAL SURGERY OF Vol․ 1
Published
2023-01-15
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2023.19.1-54

Abstract

Objectives: The purpose of this study was to comparative analysis of effectiveness of use of intradermal injections of modified hyaluronic acid (Hyalorepair 04) and its combination with platelet-rich autologous plasma in edentulous patients with perioral wrinkles of the skin. Materials and Methods: A total of 56 patient’s presence of perioral wrinkles of the skin participate in the study after dental implant prosthodontics rehabilitations. They were randomly divided into 2 groups in accordance with the applied therapy method (29 isolated implementation of modified hyaluronic acid bio-repairing and 27 biorepairing combined with autologic plasmotherapy). Treatment included implant-prosthetic rehabilitation followed by hyaluronic acid injections in order to correct cheek-zygomatic sulcus, nasolabial folds and marionette wrinkles. Preparations in an amount from 1 to 4 ml were injected into the face area, depending on the zones to be corrected at the request of the patients. Results: The complex treatment restored the aesthetic profile of the face and oral cavity and increased the effectiveness of the chewing function. On M03 and M05, 2/3 of patients had significant improvement as assessed by physician and patient according to GAIS. Most of the patients also showed significant improvement at visit M12. Conclusion: An integrated approach to the treatment of edentulous patients with perioral wrinkles increases the functional and aesthetic effect of the treatment. Implementation of combined of bioreparation and autologous plasmotherapy is significantly more effective comparatively to the isolated implementation of modified hyaluronic acid.
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