Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 286–293
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ASSOCIATION BETWEEN SALIVARY VITAMIN D3 LEVELS AND DENTAL CARIES IN CHILDREN: A CASE-CONTROL STUDY

Sandra Sagar*, Pratibha Ramani, Genickson, Sagar Moses

Senior Lecturer, Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India. · Head, Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences,Chennai, Tamilnadu, India. · Senior Resident, Department of Ophthalmology, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India · Consultant Orthodontist, Sagars Dental Clinic and Orthodontic Centre, Nagercoil, Tamilnadu, India.

Received: 2026-04-08 · Published: 2025-05-30

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
ASSOCIATION BETWEEN SALIVARY VITAMIN D3 LEVELS AND DENTAL CARIES IN CHILDREN: A CASE-CONTROL STUDY
Authors
Sandra Sagar, Pratibha Ramani, Genickson, Sagar Moses
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-05-30
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.4-286

Abstract

Background:Dental caries remains a significant global oral health concern, particularly among children. Vitamin D3 plays a crucial role in tooth mineralization and immune function, and its deficiency has been associated with increased caries risk. Traditional assessment of Vitamin D3 involves serum measurements, but saliva has recently emerged as a promising non-invasive alternative, especially in pediatric populations. Aim:This study aimed to assess salivary Vitamin D3 levels in children with dental caries compared to healthy individuals. Methods:A total of 40 children aged 10–15 years were divided into two groups: 20 children with dental caries (ICDAS II code 5) and 20 healthy controls (ICDAS II code 0). Unstimulated saliva samples were collected between 8–9 a.m., centrifuged, and stored at 4°C. Levels of 1,25-dihydroxycholecalciferol were quantified using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using a paired t-test. Results:The mean salivary Vitamin D3 level in the caries group was 30.87 ng/dL, significantly lower than the 40.125 ng/dL observed in healthy controls (p = 0.010). This suggests a strong association between Vitamin D3 deficiency and dental caries occurrence. Conclusion:Children with dental caries exhibited significantly reduced salivary Vitamin D3 levels. Salivary Vitamin D3 measurement offers a practical, non-invasive approach for early identification of caries risk, particularly in young populations. These findings support further research into the diagnostic utility of saliva-based Vitamin D assessment and its potential integration into preventive pediatric dental care.
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