Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
116–121
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BCL-2 AND MDM2 EXPRESSION IN ORAL LICHEN PLANUS: AN IMMUNOHISTOCHEMICAL STUDY

Vimalasubhashini Vivekbalamithran*, Reshma Krishnan, Deepak Pandiar

Saveetha University · Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, · Associate Professor, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

Received: 2026-01-19

© 2026 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
BCL-2 AND MDM2 EXPRESSION IN ORAL LICHEN PLANUS: AN IMMUNOHISTOCHEMICAL STUDY
Authors
Vimalasubhashini Vivekbalamithran, Reshma Krishnan, Deepak Pandiar
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.10-116

Abstract

Background: Oral lichen planus (OLP) is a chronic T-cell mediated inflammatory disease that affects the basal keratinocytes of the epithelium. Bcl-2 and MDM2 are important markers used to assess cell cycle regulation and apoptosis. The present study aimed to evaluate the expression of Bcl2 and MDM2 in oral lichen planus. Materials and methods: Thirteen histopathologically confirmed cases of OLP were included in the present study. Immunohistochemistry was performed with BCL2 and MDM2 primary antibodies and analyzed by two oral pathologists. Statistical analysis was performed using SPSS software Version 23. Results: The study comprised of 6 males and 7 females. The buccal mucosa was the most common site affected, followed by the retromolar trigone. Mild expression of BCL2 was noted in seven cases (53.8%) and moderate in one case (7.7%) of oral lichen planus. Mild expression of MDM2 was noted in three cases (23.1%) and moderate expression in nine cases (69.2%) of lichen planus. Conclusion: The findings of this study highlight that oral lichen planus (OLP) exhibit immunoexpression of MDM2 and BCL2, suggesting a potential role in apoptosis and risk of malignant transformation.
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