BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV

Ara Antonyan

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Abstract

It is shown that the amyloid beta peptides Aβ(1-16) and Aβ(1-40) and a cytokine from neurosecretory granules of bovine neurohypophysis, Proline Rich Peptide PRP-4, are truncated at the presence of multifunctional dipeptidyl peptidase IV (CD26/DPPIV), widely expressed in different mammalian tissues. It means that these neuropeptides represent substrates of the enzyme. Besides, it appeared that at the presence of CD26/DPPIV the process of Aβ(1-40) aggregation in vitro was hindered.

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BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV

Abstract

Author(s)

Table of Contents

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BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV

Abstract

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