2013; Chemical and Biological Sciences 47 (1 (230): 36–39
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BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV

Ara Antonyan*

Received: 2025-03-12 · Published: 2013-03-10

© 2013 The Author(s) and the original publisher.

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Original title
BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV
Author
Ara Antonyan
Published
2013-03-10
Licence
as stated by the publisher

Abstract

It is shown that the amyloid beta peptides Aβ(1-16) and Aβ(1-40) and a cytokine from neurosecretory granules of bovine neurohypophysis, Proline Rich Peptide PRP-4, are truncated at the presence of multifunctional dipeptidyl peptidase IV (CD26/DPPIV), widely expressed in different mammalian tissues. It means that these neuropeptides represent substrates of the enzyme. Besides, it appeared that at the presence of CD26/DPPIV the process of Aβ(1-40) aggregation in vitro was hindered.
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