2024; Chemical and Biological Sciences 58 (1 (263): 9–16
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CELL-FREE MITOCHONDRIAL DNA IN DOXORUBICIN-TREATED KCL22 AND K562 CELL LINES

Tigran A. Harutyunyan*, Anzhela A. Sargsyan, Lily A. Kalashyan, Hovhannes A. Igityan, Rouben M. Aroutiounian, Galina Hovhannisyan

Received: 2025-03-01 · Published: 2024-04-24

© 2024 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
CELL-FREE MITOCHONDRIAL DNA IN DOXORUBICIN-TREATED KCL22 AND K562 CELL LINES
Authors
Tigran A. Harutyunyan, Anzhela A. Sargsyan, Lily A. Kalashyan, Hovhannes A. Igityan, Rouben M. Aroutiounian, Galina Hovhannisyan
Published
2024-04-24
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.46991/PYSUB.2024.58.1.009

Abstract

Cell-free mitochondrial DNA (cf-mtDNA) is widely used as a biomarker of pathological processes, but its application for assessing the effects of environmental factors is limited. For the first time, cf-mtDNA was identified in the KCL22 cell culture treated with doxorubicin, which is known for its ability to disrupt mitochondrial functions. The results obtained indicate the effectiveness of using cf-mtDNA as a biomarker of genotoxic and cytotoxic effects.
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