The purpose of the work is to determine changes in tooth hard tissues, gum tissue, bone tissue of the alveolar ridge of the jaw using a model of orthodontic tooth movement in rats with experimental alimentary gastritis.
Studies were performed on 25 white Wistar rats. Assessed the condition of the teeth (the
number and depth of the carious cavities), the degree of atrophy of the alveolar ridge of the jaw. Biochemical methods were used to determine elastase activity and total proteolytic activity, alkaline and acid phosphatase in alveolar bone homogenates, calcium and phosphorus concentrations with the calculation of the ratio of calcium to phosphates, malondialdehyde content and catalase activity were determined in gum homogenates, inflammation markers (elastase activity total proteolytic activity).
Orthodontic intervention in rats with simulated gastritis contributed to a significant increase in the intensity of caries and the severity of the carious process, an increase in the degree of atrophy of the alveolar ridge of the jaw. A significant decrease in the total proteolytic activity was formed in the jaw bone tissue, an increase in the activity of acid and alkaline phosphatase was noted. In the gum tissue, a sharp intensification of lipid peroxidation (an increase in the content of malondialdehyde) and the simultaneous suppression of antioxidant protection by indicators of catalase activity were determined.
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