The evidence on the violation of chemoselectivity of aminomethylation of dimethyl- and diethylaminoethanol, which occurs under the influence of hydrogen bond was received. The same hydrogen bond occurs in the oxygen analogues of aminoethanols and β-alkoxietanols, but contrary to expectations, it is not accompanied by a change in the chemoselectivity of the reaction. We propose a rationale to explain the differences in the properties of these molecules, using charge units of the ionic character of the bond.
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Organic Chemistry
, 2025, Issue 1, pp. 1–10
ISSN Online: 0000-0000
DOI:
10.xxxx/example-doi