CHEMOSELECTIVITY OF AMINOMETHYLATION OF AMINO- AND ALKOXYETHANOLS IN CHARGE UNITS OF GENERAL THEORY OF ACIDS AND BASES

Author(s)

CHEMOSELECTIVITY OF AMINOMETHYLATION OF AMINO- AND ALKOXYETHANOLS IN CHARGE UNITS OF GENERAL THEORY OF ACIDS AND BASES Kima Petrosyan

The evidence on the violation of chemoselectivity of aminomethylation of dimethyl- and diethylaminoethanol, which occurs under the influence of hydrogen bond was received. The same hydrogen bond occurs in the oxygen analogues of aminoethanols and β-alkoxietanols, but contrary to expectations, it is not accompanied by a change in the chemoselectivity of the reaction. We propose a rationale to explain the differences in the properties of these molecules, using charge units of the ionic character of the bond.

DOI: 10.46991/PYSUB.2016.50.3.060 Chemical and Biological Sciences 50 (3 (241) 60-63

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Keywords

chemoselectivity, aminomethylation, acid of Pauling, base of Pauling

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