Bulletin of Stomatology and Maxillofacial Surgery
2025; 188–197
Shared with The Gufo

CISSUS QUADRANGULARIS INFUSED CARRAGEENAN MEMBRANES: A NATURAL POLYMER SCAFFOLD FOR PERIODONTAL TISSUE REGENERATION

Balaji Ganesh Subramanian*, Mohanapriya L, Taniya Martin, Gurumoorthy Kaarthikeyan, Sundaram Kumar

Reader, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · 2Undergraduate, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · 3Research Scholar Saveetha Dental College and hospitals, Department of Anatomy Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, · Professor and Head of Department, Department of Periodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India · .Assistant Professor, Department of Anatomy Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Tamil Nadu, India

Received: 2025-10-02 · Published: 2025-08-08

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Shared article.
Original title
CISSUS QUADRANGULARIS INFUSED CARRAGEENAN MEMBRANES: A NATURAL POLYMER SCAFFOLD FOR PERIODONTAL TISSUE REGENERATION
Authors
Balaji Ganesh Subramanian, Mohanapriya L, Taniya Martin, Gurumoorthy Kaarthikeyan, Sundaram Kumar
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-08-08
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.7-188

Abstract

A novel bioactive guided tissue regeneration (GTR) membrane was engineered by incorporating Cissus quadrangularis extract and carrageenan into a tendon-derived extracellular matrix (ECM) scaffold. The biocompatibility of the membrane was confirmed through MTT assays, while scratch wound healing assays demonstrated enhanced fibroblast migration, with Group 4—formulated with silver tricalcium phosphate—exhibiting the most significant migratory response. Gene expression profiling indicated a marked upregulation of COL1A1, VEGF-A, RUNX2, IL-10, and MMP2 in the treated groups compared to controls, suggesting the scaffold's robust potential to promote osteogenesis, angiogenesis, and anti-inflammatory activity. These results support the membrane’s application in periodontal tissue engineering, offering a multifunctional platform for regenerative therapy.
1 / ? 100% Open in new tab Download Cite

Loading the full text…

Download Follow Updates