COMBATING MULTI-DRUG RESISTANCE: POTENTIALS OF KALANCHOE PINNATA EXTRACTS AGAINST BACTERIAL PATHOGENS
Author
Muhammad Musthafa Poyil
Source journal
THE NEW ARMENIAN MEDICAL JOURNAL Volume18 (2024), Issue 3
Published
2024-08-04
Licence
as stated by the publisher
Abstract
Background: The rapid rise of microbial resistance to traditional antibiotics has caused grave concerns for the treatment of infectious diseases. This serious problem increases the demand for significant plant-based antibacterial and antimicrobial drugs. Kalanchoe pinnata is one of the plants that has had significant antibacterial effects due to the presence of a wide range of bioactive compounds, so it could be an effective substitute for the current synthetic antibiotics.
The study aimed to evaluate the anti-bacterial and antioxidant properties of a methanolic extract of Kalanchoe pinnata leaves.
Materials and Methods: The preliminary phytochemical screening was performed using
standard biochemical assays. The anti-bacterial activity was determined against multidrugresistant E. coli and S. aureus using the well-diffusion method. The 2,2-diphenyl-1-picrylhydrazyl and ferric ion reducing antioxidant potential assays were used to evaluate the antioxidant activity.
Results: The methanolic extract of Kalanchoe pinnata leaves showed the presence of flavonoids, saponins, steroids, phenol, quinones, and proteins. The remarkable anti-bacterial activities were displayed against multidrug-resistant E. coli and S. aureus, with minimum inhibitory concentration values of 50 mg/mL and 12.5 mg/mL, respectively. The significant antioxidant activity was exhibited in 2,2-diphenyl-1-picrylhydrazyl and ferric ion reducing antioxidant potential assays.
Conclusion: The results of this investigation suggested that the Kalanchoe pinnata extract may be useful as an alternative for antibiotics and may have pharmacological promise in the treatment of many diseases.
Hi! I can explain how to publish or share, find articles in your field, format citations and answer questions about fees and licensing. How can I help?
Answers are based on The Gufo’s published policies. Editorial decisions are made by the editorial team.
