Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 153–164
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COMPARATIVE ASSESSMENT OF T-PRF ALONE AND T-PRF INJECTED WITH ANTIBIOTIC GELS, HERBAL PRODUCT SEPARATELY: A HISTOLOGICAL STUDY

Shiva Shankar Gummaluri*, Kaarthikeyan Gurumoorthy, Trinath Damera, Divya Uppala, Anusha Boddeda, Ramanarayana Boyapati

Department of Periodontology and Implantology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India · Department of Periodontology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India · Head, Department of Periodontology and Implantology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India. · Head, Department of Oral Pathology and Microbiology, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India. · , Department of Periodontology , SIBAR Institute of Dental Sciences, Takkellapadu, Guntur, Andhra Pradesh, India

Received: 2026-04-08 · Published: 2025-03-20

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Originally published in Bulletin of Stomatology and Maxillofacial Surgery, 2025 — https://doi.org/10.58240/1829006X-2025.3-153.

Original title
COMPARATIVE ASSESSMENT OF T-PRF ALONE AND T-PRF INJECTED WITH ANTIBIOTIC GELS, HERBAL PRODUCT SEPARATELY: A HISTOLOGICAL STUDY
Authors
Shiva Shankar Gummaluri, Kaarthikeyan Gurumoorthy, Trinath Damera, Divya Uppala, Anusha Boddeda, Ramanarayana Boyapati
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-03-20
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.3-153

Abstract

Back ground: Antibiotics and herbal product incorporation into T-PRF are scant. Hence present study aimed to assess the fibrin network pattern, cellularity, cell distribution for T-PRF injected with metronidazole gel (MTZ), amoxicillin+ clavuanic acid (Amox-clav) gel and Neem (N) gel with T-PRF alone histologically through light microscope (LM) and scanning electron microscope (SEM). Materials and Method: Present histological study utilizes 24 healthy volunteers where 20 ml of blood was drawn; transferred to titanium tubes; centrifuged; T-PRF clots prepared; MTZ, Amox-clav and Neem gels were incorporated, compared with T-PRF alone by preparing histological slides and observed under LM and SEM. Data was subjected to statistical analysis using one-way anova, fishcer test, chi-square test and frequency distribution analysis for all the group comparisons. Results: all the groups in the present study showed non-significant results. For fibrin network pattern MTZ and Amox-clav group had shown greater percentages of thick and dense but values were non-significant (p=0.555#), cell distribution shown widerange pattern, presence of cells, all showed non-significance. Regarding mean score of cell distribution there was a range of 26- 50% (score 1-2) with non-significance (p=0.386#). Values were non-significant for SEM examination for all groups (p>0.05) Conclusion Thus within limitations T-PRF can be a sustained a drug delivery carrier system by incorporating antibiotics or herbal extract because of its thicker fibrin meshwork and greater cellular entrapment. This opens a gateway to give a new treatment protocol for treating a periodontal disease.
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