Back ground: Antibiotics and herbal product incorporation into T-PRF are scant. Hence present study aimed to assess the fibrin network pattern, cellularity, cell distribution for T-PRF injected with metronidazole gel (MTZ), amoxicillin+ clavuanic acid (Amox-clav) gel and Neem (N) gel with T-PRF alone histologically through light microscope (LM) and scanning electron microscope (SEM).
Materials and Method: Present histological study utilizes 24 healthy volunteers where 20 ml of blood was drawn; transferred to titanium tubes; centrifuged; T-PRF clots prepared; MTZ, Amox-clav and Neem gels were incorporated, compared with T-PRF alone by preparing histological slides and observed under LM and SEM. Data was subjected to statistical analysis using one-way anova, fishcer test, chi-square test and frequency distribution analysis for all the group comparisons.
Results: all the groups in the present study showed non-significant results. For fibrin network pattern MTZ and Amox-clav group had shown greater percentages of thick and dense but values were non-significant (p=0.555#), cell distribution shown widerange pattern, presence of cells, all showed non-significance. Regarding mean score of cell distribution there was a range of 26- 50% (score 1-2) with non-significance (p=0.386#). Values were non-significant for SEM examination for all groups (p>0.05)
Conclusion Thus within limitations T-PRF can be a sustained a drug delivery carrier system by incorporating antibiotics or herbal extract because of its thicker fibrin meshwork and greater cellular entrapment. This opens a gateway to give a new treatment protocol for treating a periodontal disease.
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