Bulletin of Stomatology and Maxillofacial Surgery
ISSN 1829-006X
2025; 497–504
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COMPARATIVE STUDY ON SURGICAL MARGINS AND RECURRENCE RATE IN ORAL CANCER: A PROSPECTIVE OBSERVATIONAL STUDY

Ramnarayan*, Manish Sharma, Aditi Rana

Department of Oral Medicine and Radiology, Dayananda Sagar College of Dental Sciences Bangalore. · , Department Of Oral and Maxillofacial surgery, Darshan Dental College and Hospital, Rajasthan University of health sciences, · MGM Medical college , Indore

Received: 2026-04-08 · Published: 2025-11-24

© 2025 The Author(s) and the original publisher.

CC BY-NC 4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Original title
COMPARATIVE STUDY ON SURGICAL MARGINS AND RECURRENCE RATE IN ORAL CANCER: A PROSPECTIVE OBSERVATIONAL STUDY
Authors
Ramnarayan, Manish Sharma, Aditi Rana
Source journal
Bulletin of Stomatology and Maxillofacial Surgery
Published
2025-11-24
Licence
Creative Commons Attribution-NonCommercial 4.0 International
Original
https://doi.org/10.58240/1829006X-2025.21.10-497

Abstract

Background: Surgical margin status is a pivotal determinant of recurrence and survival outcomes in oral squamous cell carcinoma. However, the clinical implications of close and involved margins remain under critical evaluation. This prospective observational study intended to scrutinize influence of histopathologically stratified surgical margins on recurrence patterns and recurrence-free survival in patients with OSCC. Methods: 90 treatment-naïve patients with T1–T3 primary OSCC were prospectively registered and grouped based on final margin status: Group A (clear margins ≥5 mm), Group B (close margins 1–4.9 mm), and Group C (involved margins <1 mm or tumor on ink). All underwent wide local excision with or without neck dissection. Follow-up evaluations were conducted over 24 months, and recurrence data were analyzed using Chi-square testing, Kaplan– Meier survival examined, and multivariate Cox regression modeling. Results: Locoregional recurrence occurred in 28 patients: 26.7% in Group A, 30.0% in Group B, and 36.7% in Group C (p = 0.53). Kaplan–Meier analysis showed a progressive decline in 24-month RFS (81.2%, 68.1%, and 55.4%, respectively). Multivariate Cox regression identified involved margins (HR = 3.21, p = 0.001) and perineural invasion (HR = 2.15, p = 0.028) as independent predictors of recurrence. Conclusion: Margin status significantly influences recurrence risk and RFS in OSCC. Even close margins confer elevated recurrence hazards, highlighting the need for precise intraoperative margin clearance and incorporation of histopathological risk factors into postoperative planning.
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